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Inhibition of Ebola Virus Infection: Identification of Niemann-Pick C1 as the Target by Optimization of a Chemical Probe
[Image: see text] A high-throughput screen identified adamantane dipeptide 1 as an inhibitor of Ebola virus (EboV) infection. Hit-to-lead optimization to determine the structure–activity relationship (SAR) identified the more potent EboV inhibitor 2 and a photoaffinity labeling agent 3. These antivi...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American
Chemical Society
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601783/ https://ncbi.nlm.nih.gov/pubmed/23526644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300370k |
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