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Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates
Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a crucial anticancer barrier. DDR inactivation in these conditions promotes genome instability and tumor progression, but the underlying molecular mechanisms are elusive. We found that overexpression of both Cyclin E an...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3601361/ https://ncbi.nlm.nih.gov/pubmed/23479741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201212058 |
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