DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells

HIV preferentially infects activated T cells, and activated mucosal CD4(+) T cells are the primary sites of viral replication. One potential explanation for increased HIV acquisition rates in the STEP study is that vaccination with adenoviral (Ad) vectors increased CD4(+) T cell activation levels at...

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Bibliographic Details
Main Authors: Reuter, Morgan A., Yuan, Sally, Marx, Preston A., Kutzler, Michele A., Weiner, David B., Betts, Michael R.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601139/
https://ncbi.nlm.nih.gov/pubmed/23111167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.22247
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