Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Ischemic Heart Failure: The FOCUS-CCTRN Trial

CONTEXT: Previous studies utilizing autologous bone marrow mononuclear cells (BMCs) in patients with ischemic cardiomyopathy have demonstrated safety and suggested efficacy. The FOCUS protocol was designed to assess efficacy of a larger cell dose in an adequately well-powered phase II study. OBJECTI...

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Autores principales: Perin, Emerson C., Willerson, James T., Pepine, Carl J., Henry, Timothy D., Ellis, Stephen G., Zhao, David X.M., Silva, Guilherme V., Lai, Dejian, Thomas, James D., Kronenberg, Marvin W., Martin, A. Daniel, Anderson, R. David, Traverse, Jay H., Penn, Marc S., Anwaruddin, Saif, Hatzopoulos, Antonis K., Gee, Adrian P., Taylor, Doris A., Cogle, Christopher R., Smith, Deirdre, Westbrook, Lynette, Chen, James, Handberg, Eileen, Olson, Rachel E., Geither, Carrie, Bowman, Sherry, Francescon, Judy, Baraniuk, Sarah, Piller, Linda B., Simpson, Lara M., Loghin, Catalin, Aguilar, David, Richman, Sara, Zierold, Claudia, Bettencourt, Judy, Sayre, Shelly L., Vojvodic, Rachel W., Skarlatos, Sonia I., Gordon, David J., Ebert, Ray F., Kwak, Minjung, Moyé, Lemuel A., Simari, Robert D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600947/
https://ncbi.nlm.nih.gov/pubmed/22447880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2012.418
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