Improved production of secreted heterologous enzyme in Bacillus subtilis strain MGB874 via modification of glutamate metabolism and growth conditions

BACKGROUND: The Bacillus subtilis genome-reduced strain MGB874 exhibits enhanced production of exogenous extracellular enzymes under batch fermentation conditions. We predicted that deletion of the gene for RocG, a bi-functional protein that acts as a glutamate dehydrogenase and an indirect represso...

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Detalhes bibliográficos
Main Authors: Manabe, Kenji, Kageyama, Yasushi, Morimoto, Takuya, Shimizu, Eri, Takahashi, Hiroki, Kanaya, Shigehiko, Ara, Katsutoshi, Ozaki, Katsuya, Ogasawara, Naotake
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600796/
https://ncbi.nlm.nih.gov/pubmed/23419162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-12-18
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