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The SLE-associated Pbx1-d isoform acts as a dominant-negative transcriptional regulator
Pbx1 is a transcription factor involved in multiple cellular processes, including the maintenance of self-renewal of hematopoietic progenitors. We have shown that the CD4 (+) T-cell expression of a novel splice isoform of Pbx1, Pbx1-d, is associated with lupus susceptibility in the NZM2410 mouse and...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600587/ https://ncbi.nlm.nih.gov/pubmed/22992721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2012.43 |
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