BCL2A1 is a lineage-specific antiapoptotic melanoma oncogene that confers resistance to BRAF inhibition

Although targeting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead to significant clinical responses in melanoma, it fails to eradicate tumors in nearly all patients. Successful therapy will be aided by identification of intrinsic mechanisms that prote...

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Bibliografiske detaljer
Main Authors: Haq, Rizwan, Yokoyama, Satoru, Hawryluk, Elena B., Jönsson, Göran B., Frederick, Dennie Tompers, McHenry, Kevin, Porter, Dale, Tran, Thanh-Nga, Love, Kevin T., Langer, Robert, Anderson, Daniel G., Garraway, Levi A., Duncan, Lyn McDivitt, Morton, Donald L., Hoon, Dave S. B., Wargo, Jennifer A., Song, Jun S., Fisher, David E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600451/
https://ncbi.nlm.nih.gov/pubmed/23447565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205575110
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