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Predictive Bcl-2 Family Binding Models Rooted in Experiment or Structure
Proteins of the Bcl-2 family either enhance or suppress programmed cell death and are centrally involved in cancer development and resistance to chemotherapy. BH3 (Bcl-2 homology 3)-only Bcl-2 proteins promote cell death by docking an α-helix into a hydrophobic groove on the surface of one or more o...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600422/ https://ncbi.nlm.nih.gov/pubmed/22617328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.05.022 |
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