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A novel, tissue-restricted zinc finger protein (HF-1b) binds to the cardiac regulatory element (HF-1b/MEF-2) in the rat myosin light-chain 2 gene.

The AT-rich element MEF-2 plays an important role in the maintenance of the muscle-specific expression of a number of cardiac and skeletal muscle genes. In the MLC-2 gene, an AT-rich element (HF-1b) which contains a consensus MEF-2 site is required for cardiac tissue-specific expression. The present...

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Udgivet i:Mol Cell Biol
Principais autores: Zhu, H, Nguyen, V T, Brown, A B, Pourhosseini, A, Garcia, A V, van Bilsen, M, Chien, K R
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360013/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8321243/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.7.4432-4444.1993
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