Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes

BACKGROUND: More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in order to identify additional biomarkers of cetuximab efficacy. METHODS: Previously...

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Main Authors: Pentheroudakis, George, Kotoula, Vassiliki, De Roock, Wendy, Kouvatseas, George, Papakostas, Pavlos, Makatsoris, Thomas, Papamichael, Demetris, Xanthakis, Ioannis, Sgouros, Joseph, Televantou, Despina, Kafiri, Georgia, Tsamandas, Athanassios C, Razis, Evangelia, Galani, Eleni, Bafaloukos, Dimitrios, Efstratiou, Ioannis, Bompolaki, Iliada, Pectasides, Dimitrios, Pavlidis, Nicholas, Tejpar, Sabine, Fountzilas, George
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599697/
https://ncbi.nlm.nih.gov/pubmed/23374602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-49
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