Ultra-deep mutant spectrum profiling: improving sequencing accuracy using overlapping read pairs

BACKGOUND: High throughput sequencing is beginning to make a transformative impact in the area of viral evolution. Deep sequencing has the potential to reveal the mutant spectrum within a viral sample at high resolution, thus enabling the close examination of viral mutational dynamics both within- a...

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Bibliografiske detaljer
Main Authors: Chen-Harris, Haiyin, Borucki, Monica K, Torres, Clinton, Slezak, Tom R, Allen, Jonathan E
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599684/
https://ncbi.nlm.nih.gov/pubmed/23402258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-96
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