Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells

BACKGROUND: Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-4 is encoded in its centrally located SAC (Selective for Apoptosis induction in...

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Main Authors: Thayyullathil, Faisal, Pallichankandy, Siraj, Rahman, Anees, Kizhakkayil, Jaleel, Chathoth, Shahanas, Patel, Mahendra, Galadari, Sehamuddin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599610/
https://ncbi.nlm.nih.gov/pubmed/23442976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-8-2
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