Allelotypes of lung adenocarcinomas featuring ALK fusion demonstrate fewer onco- and suppressor gene changes

BACKGROUND: A subset of lung adenocarcinomas harboring an EML4-ALK fusion gene resulting in dominant oncogenic activity has emerged as a target for specific therapy. EML4-ALK fusion confers a characteristic histology and is detected more frequently in never or light smokers and younger patients. MET...

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Autors principals: Ninomiya, Hironori, Kato, Motohiro, Sanada, Masashi, Takeuchi, Kengo, Inamura, Kentaro, Motoi, Noriko, Nagano, Hiroko, Nomura, Kimie, Sakao, Yukinori, Okumura, Sakae, Mano, Hiroyuki, Ogawa, Seishi, Ishikawa, Yuichi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3599044/
https://ncbi.nlm.nih.gov/pubmed/23289484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-8
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