Regional differences in prostaglandin E(2) metabolism in human colorectal cancer liver metastases

BACKGROUND: Prostaglandin (PG) E(2) plays a critical role in colorectal cancer (CRC) progression, including epithelial-mesenchymal transition (EMT). Activity of the rate-limiting enzyme for PGE(2) catabolism (15-hydroxyprostaglandin dehydrogenase [15-PGDH]) is dependent on availability of NAD+. We t...

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Detalhes bibliográficos
Main Authors: Young, Alastair L, Chalmers, Claire R, Hawcroft, Gillian, Perry, Sarah L, Treanor, Darren, Toogood, Giles J, Jones, Pamela F, Hull, Mark A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598740/
https://ncbi.nlm.nih.gov/pubmed/23442768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-92
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