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Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups

Polymer nanoparticles (PNPs) possessing a high density of drug payload have been successfully stabilized against aggregation in biological buffers after amine modification, which renders these PNPs positively charged. The resulting charge-stabilized PNPs retain their original narrow particle size di...

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Detalhes bibliográficos
Main Authors: Krovi, Sai Archana, Swindell, Elden P., O’Halloran, Thomas V., Nguyen, SonBinh T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598622/
https://ncbi.nlm.nih.gov/pubmed/23509417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2JM35420A
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