The K-fgf/hst oncogene induces transformation through an autocrine mechanism that requires extracellular stimulation of the mitogenic pathway.

Lignende værker

• Cell transformation by kFGF requires secretion but not glycosylation
  Udgivet: (1991)
• A retrovirus carrying the K-fgf oncogene induces diffuse meningeal tumors and soft-tissue fibrosarcomas.
  af: Talarico, D, et al.
  Udgivet: (1993)
• The Int-2/Fgf-3 oncogene product is secreted and associates with extracellular matrix: implications for cell transformation.
  af: Kiefer, P, et al.
  Udgivet: (1991)
• Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin
  Udgivet: (1989)
• Expression of the K-fgf proto-oncogene is controlled by 3' regulatory elements which are specific for embryonal carcinoma cells.
  af: Curatola, A M, et al.
  Udgivet: (1990)