Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA

Nucleophosmin (NPM1) is an abundant nucleolar protein implicated in ribosome maturation and export, centrosome duplication and response to stress stimuli. NPM1 is the most frequently mutated gene in acute myeloid leukemia. Mutations at the C-terminal domain led to variant proteins that aberrantly an...

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Detaylı Bibliyografya
Asıl Yazarlar: Chiarella, Sara, De Cola, Antonella, Scaglione, Giovanni Luca, Carletti, Erminia, Graziano, Vincenzo, Barcaroli, Daniela, Lo Sterzo, Carlo, Di Matteo, Adele, Di Ilio, Carmine, Falini, Brunangelo, Arcovito, Alessandro, De Laurenzi, Vincenzo, Federici, Luca
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597674/
https://ncbi.nlm.nih.gov/pubmed/23328624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt001
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