Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA

Nucleophosmin (NPM1) is an abundant nucleolar protein implicated in ribosome maturation and export, centrosome duplication and response to stress stimuli. NPM1 is the most frequently mutated gene in acute myeloid leukemia. Mutations at the C-terminal domain led to variant proteins that aberrantly an...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Chiarella, Sara, De Cola, Antonella, Scaglione, Giovanni Luca, Carletti, Erminia, Graziano, Vincenzo, Barcaroli, Daniela, Lo Sterzo, Carlo, Di Matteo, Adele, Di Ilio, Carmine, Falini, Brunangelo, Arcovito, Alessandro, De Laurenzi, Vincenzo, Federici, Luca
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2013
विषय:
Molecular Biology
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597674/
https://ncbi.nlm.nih.gov/pubmed/23328624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt001
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