Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA

Nucleophosmin (NPM1) is an abundant nucleolar protein implicated in ribosome maturation and export, centrosome duplication and response to stress stimuli. NPM1 is the most frequently mutated gene in acute myeloid leukemia. Mutations at the C-terminal domain led to variant proteins that aberrantly an...

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Hlavní autoři: Chiarella, Sara, De Cola, Antonella, Scaglione, Giovanni Luca, Carletti, Erminia, Graziano, Vincenzo, Barcaroli, Daniela, Lo Sterzo, Carlo, Di Matteo, Adele, Di Ilio, Carmine, Falini, Brunangelo, Arcovito, Alessandro, De Laurenzi, Vincenzo, Federici, Luca
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597674/
https://ncbi.nlm.nih.gov/pubmed/23328624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt001
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