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Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development
Opa1 catalyzes fusion of inner mitochondrial membranes and formation of the cristae. OPA1 mutations in humans lead to autosomal dominant optic atrophy. OPA1 knockout mice lose viability around embryonic day 9 from unknown reasons, indicating that OPA1 is essential for embryonic development. Zebrafis...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3597633/ https://ncbi.nlm.nih.gov/pubmed/23516612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059218 |
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