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Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development

Opa1 catalyzes fusion of inner mitochondrial membranes and formation of the cristae. OPA1 mutations in humans lead to autosomal dominant optic atrophy. OPA1 knockout mice lose viability around embryonic day 9 from unknown reasons, indicating that OPA1 is essential for embryonic development. Zebrafis...

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Bibliographic Details
Main Authors: Rahn, Jennifer J., Stackley, Krista D., Chan, Sherine S. L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597633/
https://ncbi.nlm.nih.gov/pubmed/23516612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059218
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