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Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells

Testicular development in the mouse is triggered in somatic cells by the function of Sry followed by the activation of fibroblast growth factor 9 (FGF9), which regulates testicular differentiation in both somatic and germ cells. However, the mechanism is unknown. We show here that the nodal/activin...

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Detalhes bibliográficos
Main Authors: Wu, Quan, Kanata, Kohei, Saba, Rie, Deng, Chu-Xia, Hamada, Hiroshi, Saga, Yumiko
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597207/
https://ncbi.nlm.nih.gov/pubmed/23221368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.087882
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