Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8 (SAMP8) mice

Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist approved for the treatment of moderate to severe Alzheimer's disease (AD). Environmental enrichment (EE) has shown significant beneficial effects on functional improvement in AD. In this study, we sought to determine whether combini...

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Detalhes bibliográficos
Main Authors: Dong, Jingde, Zhou, Mi, Wu, Xiaoqiang, Du, Mingyang, Wang, Xiaoshan
Formato: Artigo
Idioma:Inglês
Publicado em: Editorial Department of Journal of Biomedical Research 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597048/
https://ncbi.nlm.nih.gov/pubmed/23554783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7555/JBR.26.20120053
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