Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients

OBJECTIVES: The aim of this study was to investigate the frequency of CYP2B6 polymorphisms (according to ethnicity) and the influence of heterozygosity and homozygosity on plasma concentrations of efavirenz and nevirapine. METHODS: Following written informed consent, 225 Caucasians and 146 Blacks we...

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Main Authors: Wyen, Christoph, Hendra, Heidy, Vogel, Martin, Hoffmann, Christian, Knechten, Heribert, Brockmeyer, Norbert H., Bogner, Johannes R., Rockstroh, Jürgen, Esser, Stefan, Jaeger, Hans, Harrer, Thomas, Mauss, Stefan, van Lunzen, Jan, Skoetz, Nicole, Jetter, Alexander, Groneuer, Christiane, Fätkenheuer, Gerd, Khoo, Saye H., Egan, Deirdre, Back, David J., Owen, Andrew
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596857/
https://ncbi.nlm.nih.gov/pubmed/18281305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkn029
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