Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma()

Exhaled breath nitric oxide (NO) is an accepted asthma biomarker. Lung concentrations of NO and its amino acid precursor, L-arginine, are regulated by the relative expressions of the NO synthase (NOS) and arginase isoforms. Increased expression of arginase I and NOS2 occurs in murine models of aller...

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Bibliographic Details
Main Authors: Bratt, Jennifer M., Zeki, Amir A., Last, Jerold A., Kenyon, Nicholas J.
Format: Artigo
Language:Inglês
Published: Editorial Department of Journal of Biomedical Research 2011
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596726/
https://ncbi.nlm.nih.gov/pubmed/23554705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1674-8301(11)60041-9
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