5-HT(3) receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells

BACKGROUND AND PURPOSE: Chemotherapeutic agents, including 5-fluorouracil (5-FU), frequently cause intestinal mucositis resulting in severe diarrhoea and morphological mucosal damage. 5-HT(3) receptor antagonists are clinically effective in the treatment of nausea and emesis during cancer chemothera...

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Autors principals: Yasuda, M, Kato, S, Yamanaka, N, Iimori, M, Matsumoto, K, Utsumi, D, Kitahara, Y, Amagase, K, Horie, S, Takeuchi, K
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596644/
https://ncbi.nlm.nih.gov/pubmed/23072534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12019
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