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Proopiomelanocortin (POMC) expression and conditioned place aversion during protracted withdrawal from chronic intermittent escalating-dose heroin in POMC-EGFP promoter transgenic mice

In heroin-dependent individuals, the drive to avoid or ameliorate the negative affective/emotional state associated with the discontinuation of heroin contributes to the chronic relapsing nature of the disease. Here, we investigate changes in proopiomelanocortin (POMC) expression at three time point...

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Autori principali: Niikura, Keiichi, Zhou, Yan, Ho, Ann, Kreek, Mary Jeanne
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596435/
https://ncbi.nlm.nih.gov/pubmed/23337531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.12.071
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