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Role of the ligand in intracellular receptor function: receptor affinity determines activation in vitro of the latent dioxin receptor to a DNA-binding form.

To reconstitute the molecular mechanisms underlying the cellular response to soluble receptor ligands, we have exploited a cell-free system that exhibits signal- (dioxin-)induced activation of the latent cytosolic dioxin receptor to an active DNA-binding species. The DNA-binding properties of the in...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Principais autores: Cuthill, S, Wilhelmsson, A, Poellinger, L
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1991
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359640/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1986235/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.1.401-411.1991
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