Gadd45g Is Essential for Primary Sex Determination, Male Fertility and Testis Development

In humans and most mammals, differentiation of the embryonic gonad into ovaries or testes is controlled by the Y-linked gene SRY. Here we show a role for the Gadd45g protein in this primary sex differentiation. We characterized mice deficient in Gadd45a, Gadd45b and Gadd45g, as well as double-knocko...

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Detalhes bibliográficos
Main Authors: Johnen, Heiko, González-Silva, Laura, Carramolino, Laura, Flores, Juana Maria, Torres, Miguel, Salvador, Jesús M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596291/
https://ncbi.nlm.nih.gov/pubmed/23516551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058751
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