DENDRITIC CELLS WITH TGF-ß1 and IL-2 DIFFERENTIATE NAÏVE CD4+ T CELLS INTO ALLOANTIGEN SPECIFIC AND ALLOGRAFT PROTECTIVE FOXP3+ REGULATORY T CELLS

BACKGROUND: Naturally occurring, thymic-derived Foxp3+CD25+CD4+ regulatory T cells (natural Tregs) are pivotal for the maintenance of self-tolerance. Natural Tregs, however, are sparse and lack alloantigen specificity and these properties pose challenges for their use in clinical transplantation. ME...

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Main Authors: Yang, Hua, Cheng, Elaine Y, Sharma, Vijay K, Lagman, Mila, Chang, Christina, Song, Ping, Ding, Ruchuang, Muthukumar, Thangamani, Suthanthiran, Manikkam
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595618/
https://ncbi.nlm.nih.gov/pubmed/22270834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e318244dd67
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