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Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain.

The erb A oncogene is a dominant negative allele of a thyroid hormone receptor gene and acts in the cancer cell by encoding a transcriptional repressor. We demonstrate here that the DNA sequence recognition properties of the oncogenic form of the erb A protein are significantly altered from those of...

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Bibliografiske detaljer
Udgivet i:Mol Cell Biol
Main Authors: Chen, H, Smit-McBride, Z, Lewis, S, Sharif, M, Privalsky, M L
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1993
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359557/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8096060/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.4.2366
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