Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in humans. Here, we show that gliomas can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cel...

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Autores principales: Friedmann-Morvinski, Dinorah, Bushong, Eric A., Ke, Eugene, Soda, Yasushi, Marumoto, Tomotoshi, Singer, Oded, Ellisman, Mark H., Verma, Inder M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595315/
https://ncbi.nlm.nih.gov/pubmed/23087000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1226929
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