The Akt Inhibitor ISC-4 Synergizes with Cetuximab in 5-FU-Resistant Colon Cancer

Phenylbutyl isoselenocyanate (ISC-4) is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. In this study, we sought to improve the clinical utility of ISC-4 by identifying a synergistic combination with FDA-approved anti-cancer therapies, a relevant and approp...

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Detalhes bibliográficos
Main Authors: Allen, Joshua E., Gallant, Jean-Nicolas, Dicker, David T., Amin, Shantu, Irby, Rosalyn B., Sharma, Arun K., El-Deiry, Wafik S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595267/
https://ncbi.nlm.nih.gov/pubmed/23555026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059380
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