Blocking the effects of interleukin-6 in rheumatoid arthritis and other inflammatory rheumatic diseases: systematic literature review and meta-analysis informing a consensus statement

BACKGROUND: Suppression of the immunoinflammatory cascade by targeting interleukin 6 (IL-6) mediated effects constitutes a therapeutic option for chronic inflammatory diseases. Tocilizumab is the only IL-6 inhibitor (IL-6i) licensed for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JI...

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Autori principali: Schoels, Monika M, van der Heijde, Désirée, Breedveld, Ferdinand C, Burmester, Gerd R, Dougados, Maxime, Emery, Paul, Ferraccioli, Gianfranco, Gabay, Cem, Gibofsky, Allan, Gomez-Reino, Juan Jesus, Jones, Graeme, Kvien, Tore K, Murikama, Miho M, Nishimoto, Norihiro, Smolen, Josef S
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2013
Soggetti:
Clinical and Epidemiological Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595140/
https://ncbi.nlm.nih.gov/pubmed/23144446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-202470
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