Extinction of T cell receptor alpha-chain gene expression accompanied by loss of the lymphoid enhancer-binding factor 1 (LEF-1) in murine somatic cell hybrids.

To investigate the presence of a negative regulatory factor(s) suppressing T-cell receptor alpha-chain (TCR alpha) gene expression in non-T cells, 10 independent cell hybrid clones were generated between mouse T-cell lymphoma EL4 cells (TCR alpha+/beta+) and mouse fibroblast B82 cells. These cell hy...

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Detalhes bibliográficos
Main Authors: Yamada, T, Hitomi, Y, Shimizu, K, Ohki, M, Oikawa, T
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC359508/
https://ncbi.nlm.nih.gov/pubmed/8382779
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