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Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

The abundance of the mRNA for human triosephosphate isomerase (TPI) is decreased to approximately 20% of normal by frameshift and nonsense mutations that cause translation to terminate at a nonsense codon within the first three-fourths of the reading frame. Results of previous studies inhibiting RNA...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Biol
Autori principali: Cheng, J, Maquat, L E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1993
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359503/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8441420/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.3.1892
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