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Deletion of the UL4 gene sequence of equine herpesvirus 1 precludes the generation of defective interfering particles

Serial, high multiplicity passage of equine herpesvirus 1 (EHV-1) leads to the generation of defective interfering particles (DIP). EHV-1 DIP inhibit and interfere with the replication of standard EHV-1, establishing a state of persistent infection. These DIP package severely truncated and rearrange...

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Bibliografske podrobnosti
Main Authors: Charvat, Robert A., Zhang, Yunfei, O’Callaghan, Dennis J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595000/
https://ncbi.nlm.nih.gov/pubmed/22752566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11262-012-0781-2
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