8-Plex Quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer’s disease

An 8-plex version of an isobaric reagent for the quantitation of proteins using shotgun methods is presented. The 8-plex version of the reagent relies on amine-labeling chemistry of peptides similar to 4-plex reagents. MS/MS reporter ions at 113, 114, 115, 116, 117, 118, 119, and 121 m/z are used to...

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Main Authors: Choe, Leila, D’Ascenzo, Mark, Relkin, Norman R., Pappin, Darryl, Ross, Phil, Williamson, Brian, Guertin, Steven, Pribil, Patrick, Lee, Kelvin H.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594777/
https://ncbi.nlm.nih.gov/pubmed/17880003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.200700316
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