Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA

Many studies have shown decreased cortical muscarinic M1 receptors (CHRM1) in schizophrenia (Sz), with one study showing Sz can be separated into two populations based on a marked loss of CHRM1 (∼75%) in ∼25% of people (Def-Sz) with the disorder. To better understand the mechanism contributing to th...

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Detalhes bibliográficos
Main Authors: Scarr, E, Craig, J M, Cairns, M J, Seo, M S, Galati, J C, Beveridge, N J, Gibbons, A, Juzva, S, Weinrich, B, Parkinson-Bates, M, Carroll, A P, Saffery, R, Dean, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594731/
https://ncbi.nlm.nih.gov/pubmed/23423139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2013.3
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