Plasma and Intracellular Pharmacokinetics of Darunavir/Ritonavir Once Daily and Raltegravir Once and Twice Daily in HIV-Infected Individuals

OBJECTIVES: To investigate the pharmacokinetics of darunavir/ritonavir and raltegravir, in HIV-infected subjects, in both plasma and at the intracellular (IC) site of action. METHODS: HIV-infected patients on antiretroviral therapy received raltegravir 400 mg twice daily for 21 days (period 1); daru...

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Hlavní autoři: Jackson, Akil, Watson, Victoria, Back, David, Khoo, Saye, Liptrott, Neill, Egan, Deidre, Gedela, Keerti, Higgs, Chris, Abbas, Riaz, Gazzard, Brian, Boffito, Marta
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594701/
https://ncbi.nlm.nih.gov/pubmed/21926632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3182364c67
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