A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors

BACKGROUND AND PURPOSE: Most GABA(A) receptor subtypes comprise 2α, 2β and 1γ subunit, although for some isoforms, a δ replaces a γ-subunit. Extrasynaptic δ-GABA(A) receptors are important therapeutic targets, but there are few suitable pharmacological tools. We profiled DS2, the purported positive...

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Autori principali: Jensen, ML, Wafford, KA, Brown, AR, Belelli, D, Lambert, JJ, Mirza, NR
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594672/
https://ncbi.nlm.nih.gov/pubmed/23061935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12001
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