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Phosphorylation of connexin43 on S279/282 may contribute to laminopathy-associated conduction defects

An understanding of the molecular mechanism behind the arrhythmic phenotype associated with laminopathies has yet to emerge. A-type lamins have been shown to interact and sequester activated phospho-ERK1/2(pERK1/2) at the nucleus. The gap junction protein connexin43 (Cx43) can be phosphorylated by p...

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Detalhes bibliográficos
Main Authors: Chen, Steven C., Kennedy, Brian K., Lampe, Paul D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594536/
https://ncbi.nlm.nih.gov/pubmed/23261543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2012.12.014
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