The Modulation of Hepatitis C Virus 1a Replication by PKR is Dependent on NF-kB Mediated Interferon Beta Response in Huh7.5.1 Cells

Protein kinase R (PKR), a sensor of double-stranded RNA, plays an important role in the host response to viral infection. Hepatitis C genotype 2a virus (HCV 2a) has been shown to induce PKR activation to suppress the translation of antiviral interferon stimulated genes (ISGs), suggesting that PKR in...

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Bibliographic Details
Main Authors: Zhang, Lumin, Alter, Harvey J., Wang, Haiping, Jia, Shuaizheng, Wang, Ena, Marincola, Francesco M., Shih, Jams W-K., Wang, Richard Y.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594529/
https://ncbi.nlm.nih.gov/pubmed/23399035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.01.015
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