CXCR4/CXCL12 mediate autocrine cell cycle progression in NF1-associated malignant peripheral nerve sheath tumors

Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are soft tissue sarcomas that arise in connective tissue surrounding peripheral nerves. They occur sporadically in a subset of patients with Neurofibromatosis type-1 (NF1). MPNSTs are highly aggressive, therapeutically resistant, and typically fatal....

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Autori principali: Mo, Wei, Chen, Jian, Patel, Amish, Zhang, Liang, Chau, Vincent, Li, Yanjiao, Cho, Woosung, Lim, Kyun, Xu, Jing, Lazar, Alexander J., Creighton, Chad J., Bolshakov, Svetlana, McKay, Renée M., Lev, Dina, Le, Lu Q., Parada, Luis F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594500/
https://ncbi.nlm.nih.gov/pubmed/23434321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.01.053
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