Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes

OBJECTIVES: The enhanced intracellular survival (Eis) protein from Mycobacterium tuberculosis (Eis_Mtb), a regio-versatile N-acetyltransferase active towards many aminoglycosides (AGs), confers resistance to kanamycin A in some cases of extensively drug-resistant tuberculosis (XDR-TB). We assessed t...

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Autori principali: Houghton, Jacob L., Green, Keith D., Pricer, Rachel E., Mayhoub, Abdelrahman S., Garneau-Tsodikova, Sylvie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594498/
https://ncbi.nlm.nih.gov/pubmed/23233486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks497
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