Cu(2+) Affects Amyloid-β (1–42) Aggregation by Increasing Peptide-Peptide Binding Forces

The link between metals, Alzheimer's disease (AD) and its implicated protein, amyloid-β (Aβ), is complex and highly studied. AD is believed to occur as a result of the misfolding and aggregation of Aβ. The dyshomeostasis of metal ions and their propensity to interact with Aβ has also been impli...

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Bibliographic Details
Main Authors: Hane, Francis, Tran, Gary, Attwood, Simon J., Leonenko, Zoya
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594192/
https://ncbi.nlm.nih.gov/pubmed/23536847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059005
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