Virus-like Particles Containing Multiple M2 Extracellular Domains Confer Improved Cross-protection Against Various Subtypes of Influenza Virus

The extracellular domain of M2 (M2e), a small ion channel membrane protein, is well conserved among different human influenza A virus strains. To improve the protective efficacy of M2e vaccines, we genetically engineered a tandem repeat of M2e epitope sequences (M2e5x) of human, swine, and avian ori...

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Autors principals: Kim, Min-Chul, Song, Jae-Min, O, Eunju, Kwon, Young-Man, Lee, Youn-Jeong, Compans, Richard W, Kang, Sang-Moo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594028/
https://ncbi.nlm.nih.gov/pubmed/23247101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.246
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