Efficacy of the investigational mTOR kinase inhibitor MLN0128 / INK128 in models of B-cell acute lymphoblastic leukemia

The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase whose activity contributes to leukemia proliferation and survival. Compounds targeting the mTOR active site inhibit rapamycin-resistant functions and have enhanced anti-cancer activity in mouse models. MLN0128 (formerly known as...

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Main Authors: Janes, Matthew R., Vu, Collin, Mallya, Sharmila, Shieh, Marie, Limon, Jose J., Li, Lian-Sheng, Jessen, Katti A., Martin, Michael B., Ren, Pingda, Lilly, Michael B., Sender, Leonard, Liu, Yi, Rommel, Christian, Fruman, David A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593948/
https://ncbi.nlm.nih.gov/pubmed/23090679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.276
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