Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA

Human TRF1-binding protein PinX1 inhibits telomerase activity. Here we report that overexpression of yeast PinX1p (yPinX1p) results in shortened telomeres and decreased in vitro telomerase activity. yPinX1p coimmunoprecipitated withyeast telomerase protein Est2p even in cells lacking the telomerase...

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Bibliografische gegevens

Gepubliceerd in:	Genes Dev
Hoofdauteurs:	Lin, Jue, Blackburn, Elizabeth H.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Cold Spring Harbor Laboratory Press 2004
Onderwerpen:	Research Papers
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359393/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14977919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1171804
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