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Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry

Double-stranded DNA (dsDNA) unconstrained by torsion undergoes an overstretching transition at about 65 pN, elongating the DNA to about 1.7-fold. Three possible structural transitions have been debated for the nature of DNA overstretching: (i) “peeling” apart of dsDNA to produce a peeled ssDNA stran...

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Detalhes bibliográficos
Main Authors: Zhang, Xinghua, Chen, Hu, Le, Shimin, Rouzina, Ioulia, Doyle, Patrick S., Yan, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593865/
https://ncbi.nlm.nih.gov/pubmed/23431154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213740110
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