5-Aza-2′-Deoxycytidine Has Minor Effects on Differentiation in Human Thyroid Cancer Cell Lines, But Modulates Genes That Are Involved in Adaptation In Vitro

BACKGROUND: In thyroid cancer, the lack of response to specific treatment, for example, radioactive iodine, can be caused by a loss of differentiation characteristics of tumor cells. It is hypothesized that this loss is due to epigenetic modifications. Therefore, drugs releasing epigenetic repressio...

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Detalhes bibliográficos
Main Authors: Dom, Geneviève, Galdo, Vanessa Chico, Tarabichi, Maxime, Tomás, Gil, Hébrant, Aline, Andry, Guy, De Martelar, Viviane, Libert, Frédérick, Leteurtre, Emmanuelle, Dumont, Jacques E., Maenhaut, Carine, van Staveren, Wilma C.G.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Thyroid Cancer and Nodules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593687/
https://ncbi.nlm.nih.gov/pubmed/23167291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2012.0388
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